Papilocare Vaginal Gel 21 canulas of 5 ml

Product Information

Curso de Colposcopia de la Asociación Española de Patología Cervical y Colposcopia. Disponible en http://www.aepcc.org/ Acceso: 07/09/15. Papilocare Immunocaps has a unique and complete composition based on Reishi extract, a therapeutic fungus similar to Coriolus versicolor, different species of probiotic lactobacilli (L crispatus, L rhamnosus and L gasseri) and a multivitamin compound in which Quatrefolic stands out, the active and assimilable form of folic acid, essential for the proper functioning of the immune system. Persoanele cu sensibilitate crescută la oricare dintre ingredientele din Papilocare Gel Vaginal pot prezenta reacții alergice, cum ar fi mâncărime, erupții cutanate, umflături sau dificultăți de respirație. În astfel de cazuri, trebuie întreruptă imediat utilizarea gelului și trebuie solicitat sfatul medical. Neem extract): има омекотяващо действие, което засилва естествения процес на заздравяване и намалява зачервяването и сърбежа.

You can use Papilocare® at any time of day, but the gel is more likely to remain in place if you apply it just before bedtime.Papilocare Gel Vaginal poate fi utilizat ca parte a tratamentului leziunilor intraepiteliale la nivelul mucoasei cervico-vaginale, grăbind procesul de vindecare și favorizând regenerarea țesuturilor afectate. mai puțin decât recomandat deoarece cantitatea eliberată din aplicator este suficientă pentru a acoperi care sunt deschise sau deteriorate trebuie aruncate. Aplicatorul este conceput pentru o aplicare mai ușoară

In the PALOMA trial, Papilocare ® demonstrated efficacy in repairing low-grade cervical lesions related to human papillomavirus (HPV). This sub-analysis aimed to evaluate its efficacy in repairing these cervical lesions and clearing HPV in women aged older than 40 years. This was a multicenter, randomized, open-label, parallel-group, controlled clinical trial. Patients with low-degree HPV-dependent cervical lesions receiving 6-month treatment with the vaginal gel were compared to those with a watchful waiting approach. Among the 41 women analyzed (aged 47.7 years), 31 presented high-risk (HR) oncogenic HPV subtypes, and 14 had 16-18-31 HPV genotypes. After 6 months, normalized cytology and concordant colposcopy were achieved by a greater percentage of treated women. The difference was significant in the total population (92.3% vs. 50.0%, p = 0.007), and HR-HPV subpopulation (90.5% vs. 33.3%, p = 0.003). In the HR HPVs-16-18-31 subpopulation, the values were 75.0% and 40.0% ( p = 0.293). In the total population, 61.5% of treated patients obtained HPV clearance, compared to 50.0% in the control group. Regarding the HR-HPV subpopulation, these values were 66.7% and 44.4%, respectively. Papilocare ® demonstrated significant efficacy in repairing low-degree HPV-related cervical lesions and a positive trend to clear HPV in women older than 40 years old in comparison to the watchful waiting approach. Laura, 32 años: «Después de ser diagnosticada con VPH y tener lesiones cervicales, mi médico me recomendó usar Papilocare. Después de un par de ciclos de tratamiento, las lesiones se redujeron significativamente y mi médico quedó impresionado con los resultados. Estoy muy agradecida por este producto y lo recomiendo a cualquiera que esté luchando con el VPH». The human papillomavirus (HPV) is one of the most common sexually transmitted infections and the most important etiological agent in cervical cancer. 1 Most HPV infections are asymptomatic and clear within 2 years without treatment. 2 Despite its low risk of progression to cervical cancer, many women experience negative emotional responses and even long-term psychological distress associated with an HPV-positive diagnosis and an abnormal cytology. 3, 4 When added to the fact that the conventional management strategy for this condition, especially in cases of low-grade lesion, is watchful waiting, the approach may become long and challenging for both the women and their physicians. Thus, a safe and nonsurgical treatment that can help repair the low-grade lesions and enhance viral clearance might be highly useful under these circumstances. 5 Papilocare (Procare Health, Valencia, Spain) is a Coriolus versicolor–based vaginal gel that combines ingredients boasting known properties, such as moisturizing, tissue regeneration, and balancing of the vaginal microbiota (hyaluronic acid, Asian centella, Aloe vera, and α-glucan oligosaccharide), 6, 7 with other ingredients with demonstrated positive effects on both HPV-dependent cervical lesions and HPV clearance ( C. versicolor, Azadirachta indica, and carboxymethyl-β-glucan). 8– 10 It has been hypothesized that HPV integration could be minimized by reducing the potential mitotic surface by re-epithelization. 11 On the other hand, the vaginal microbiota status plays a decisive role in the persistence or clearance of local infections. 12– 14 Improved re-epithelization and vaginal microbiota restoration have been observed in previous pilot studies involving the use of Papilocare in both asymptomatic, healthy women and HPV-positive patients with no cervical lesions. 15, 16 Moreover, a combination of C. versicolor and neem extract has shown to induce a local immune response in both in vitro and animal model studies 17– 19 hindering the oncogenic action of the HPV.Obstetrics and Gynaecology Department, Hospital Universitario Infanta Leonor, Av. Gran Vía del Este, 80, 28031 Madrid, Spain. Papilocare se presenta en forma de gel en un tubo con aplicador, lo que facilita su aplicación y dosificación. El aplicador está diseñado para garantizar una distribución uniforme del gel en la zona vaginal, maximizando su eficacia y minimizando el riesgo de irritación o molestias. El envase de Papilocare contiene suficiente gel para un ciclo completo de tratamiento, y las instrucciones detalladas de uso se incluyen en el prospecto que acompaña al producto. Beneficios de Papilocare Niosomas de ácido láctico: Los niosomas son partículas microscópicas que encapsulan y liberan lentamente el ácido láctico, un componente clave para mantener el equilibrio del pH vaginal y prevenir el crecimiento de bacterias y otros microorganismos dañinos.

Coriolus versicolor; age; cervical lesions; clearance; high risk; human papillomavirus; vaginal gel. Formarea unei bariere de aparare in zona de transformare a colului uterin pentru a preveni riscul de patrundere a HPV. Repair of HPV-dependent cervical lesions after 3 and 6 months of treatment in the total and HR HPV patient pools. *Normalized cytology together with concordant colposcopic observations. **χ 2 test. One high-risk HPV patient of the control group had missing data. Overall HPV Clearance A nonstatistically significant trend toward a higher HPV clearance was observed at 6 months in the treatment group (31/52 [59.6%] of the patients, with missing data for 1 patient) compared with the control group (41.9% [13/31], p = .118). Scheme B with Papilocare showed significant differences in clearance compared with the control group (75.9% vs 41.9%, p = .008), whereas no significant differences were observed with scheme A (39.1% vs 41.9%, p = .836). In the HR HPV group, a trend toward greater clearance was observed among the treated patients compared with the control group (62.5% vs 40.0%, p = .076). In this patient cohort, scheme B also resulted in significant differences in clearance with respect to the control group (81.8% vs 40.0%, p = .004), whereas scheme A did not (38.9% vs 40.0%, nonsignificant). Cervical Re-epithelization Coriolus versicolor: actiune reepitelizanta a leziunilor si micro-leziunilor de la nivelul zonei cervico-vaginale.Aplicati o canula cu doza unica in zona vaginala, de preferinta inainte de culcare. Apasati recipientul pentru a goli continutul acestuia si indepartati-l usor, fara clatire.

The aim of the study was to evaluate the efficacy of Papilocare, a Coriolus versicolor–based vaginal gel, in repairing human papillomavirus (HPV)-related low-grade cervical lesions. Methods membrana mucoasă a colului uterin și a vaginului (3 ml). După utilizare, aplicatorul trebuie aruncat. Aplicator cazuri rare, utilizarea Papilocare Gel Vaginal poate fi asociată cu tulburări digestive minore, cum ar fi greață sau disconfort la nivelul stomacului. Dacă aceste simptome persistă sau devin deranjante, este recomandat să cereți sfatul medicului. Controlul si reepitelizarea zonei de transformare a colului uterin pentru a preveni riscul de aparitie a leziunilor (LSIL) cauzate de HPV.Papilocare® galima įsigyti kaip vienos dozės aplikatorių, skirtą naudoti makštyje. Visi aplikatoriai Mod de depozitare: A se pastra la o temperatura cuprinsa intre 2 °C si 25 °C. A nu se lăsa la îndemâna copiilor. Obstetrics and Gynaecology Department, Hospital General Universitario, C. Pintor Baeza, 11, 03010 Alicante, Spain. The human papillomavirus (HPV) is one of the most common sexually transmitted infections and the most important etiological agent in cervical cancer. 1 Most HPV infections are asymptomatic and clear within 2 years without treatment. 2 Despite its low risk of progression to cervical cancer, many women experience negative emotional responses and even long-term psychological distress associated with an HPV-positive diagnosis and an abnormal cytology. 3,4 When added to the fact that the conventional management strategy for this condition, especially in cases of low-grade lesion, is watchful waiting, the approach may become long and challenging for both the women and their physicians. Thus, a safe and nonsurgical treatment that can help repair the low-grade lesions and enhance viral clearance might be highly useful under these circumstances. 5 Papilocare (Procare Health, Valencia, Spain) is a Coriolus versicolor–based vaginal gel that combines ingredients boasting known properties, such as moisturizing, tissue regeneration, and balancing of the vaginal microbiota (hyaluronic acid, Asian centella, Aloe vera, and α-glucan oligosaccharide), 6,7 with other ingredients with demonstrated positive effects on both HPV-dependent cervical lesions and HPV clearance ( C. versicolor, Azadirachta indica, and carboxymethyl-β-glucan). 8–10 It has been hypothesized that HPV integration could be minimized by reducing the potential mitotic surface by re-epithelization. 11 On the other hand, the vaginal microbiota status plays a decisive role in the persistence or clearance of local infections. 12–14 Improved re-epithelization and vaginal microbiota restoration have been observed in previous pilot studies involving the use of Papilocare in both asymptomatic, healthy women and HPV-positive patients with no cervical lesions. 15,16 Moreover, a combination of C. versicolor and neem extract has shown to induce a local immune response in both in vitro and animal model studies 17–19 hindering the oncogenic action of the HPV. Hyaluronic acid niosomes): основното им свойство е повърхностно овлажняване на тъканите, придавайки им еластичност.