AREDS2 VISION DEFENDER AMD Supplement: Lutein, Zeaxanthin, Zinc, Vitamin E – AREDS 2 Eye Vitamins, Minerals, Nutrients for Eyes. 3 Months Supply (90 tablets) One-A-Day Vegan Eye Supplement. Made in UK

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Play a vital role in retinal cell survival and are crucial for the normal functioning of antioxidant enzymes RECOMMENDED BY LEADING EYE SPECIALISTS – The AREDS2 formula is recommended by doctors and eye-care professionals because it is clinically proven. The AREDS2 research showed the benefits of nutritional support in AMD and has become the gold standard in AMD eye health. Vision Defender AMD eye supplement conforms exactly to AREDS2 recommendations so you can be confident that it works to care for your eyes and help maintain normal vision. Seddon JM, Rosner B, Sperduto RD, et al. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol. 2001;119(8):1191-9. doi:10.1001/archopht.119.8.1191. During the AREDS trial, two large trials funded by the National Cancer Institute found that beta-carotene may increase lung cancer risk among people who smoke. Lutein and zeaxanthin are in the same family of nutrients as beta-carotene and are believed to have important functions in the retina. Lutein and zeaxanthin have not been associated with increased cancer risk.

Antioxidants reduce this harmful effect. Vitamins A, C and E are antioxidants. Carotenoids are also effective against oxidants. Lutein and zeaxanthin are important carotenoids. Many of these substances can only be obtained from food. An optometrist or ophthalmologist may see “drusen” when they examine your retina. Drusen are small deposits under the retina, which they can see as yellow dots. Drusen can be present as a normal part of ageing and are not always a sign that someone has AMD. Dunaief J. Lutein and zeaxanthin for protection against macular degeneration. Bright Focus Foundation. Drusen are made up of cellular waste materials that collect under the retina. These white or yellow deposits are a common early sign of AMD. The AREDS2 supplements are not available on prescription.

Macushield Gold is formulated to be the exact same combination as that used in the 2nd phase of the AREDS trial. Zinc oxide 80 mg or 25 mg:Zinc is a trace mineral, thought to play an important role in the function of the retina. Zinc depletion results in difficulty with adapting to night vision and other reduced functions of the retina. Gaziano JM, Glynn RJ, et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2009 Jan 7;301(1):52-62. doi: 10.1001/jama.2008.862. https://pubmed.ncbi.nlm.nih.gov/19066368/ They reviewed the evidence around the use of these supplements, which includes the two large scale studies, AREDS and AREDS 2. They found that the evidence that they benefit people with AMD was not strong enough to recommend that people take these supplements. NICE have recommended that further large-scale studies are needed before they can be confident that the AREDS2 formula is effective at preventing worsening of AMD.

Some studies have suggested that exposure to high levels of sunlight (particularly the UV light contained in sunlight) throughout your life may increase your risk of developing AMD, but this has not been proven. However, wearing sunglasses to protect your eyes from the UV light in sunlight is a good idea for everyone throughout their life. Monitoring vision and regular eye examinations Age-Related Eye Disease Study Research Group, SanGiovanni JP, Chew EY, et al. The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol. 2007 Sep;125(9):1225-32. doi: 10.1001/archopht.125.9.1225. https://pubmed.ncbi.nlm.nih.gov/17846363/ At present the strongest evidence about which vitamin formula to take comes from AREDS (2001) and AREDS2 (2012), two large-scale clinical trials carried out in the United States.Vitamin C 500 mg: Vitamin C is a vitamin that is present throughout all parts of the retina of the eye and is thought to be protective against AMD. Similarly, the daily dose of Vitamin C is only 80mg (versus 500mg in AREDS2), Zinc only 10mg (versus 25mg), and Copper only 0.5mg (versus 2mg). This is giving people false assurance because they think that they are taking an “AREDS2 supplement” but in reality they are not! One can only imagine that the makers of MacuXXXXX gives you less than that recommended in AREDS2 because it’s cheaper for them to make and can sell their product cheaply…and there are many other “AREDS2 supplements” like this! Recommendations: A supplement containing both bilberry extract 80mg (standardised to 36% anthocyanins) and pine bark extract 40mg (standardised to 70% procyanidins). The studies show that this combination needs to be taken for a minimum of 3 months and preferably 6 months or more for optimal effect.

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Vitamin supplementation with AREDS2 Vitamin combinations such as VisuBright is an easy way to be proactive about your eye health and reduce the risk of AMD progression and associated vision loss. Zeaxanthin 2 mg: Zeaxanthin is also a carotenoid.The body does not produce its own zeaxanthin; it must obtain zeaxanthin from the diet as well. Recommendations: A supplement containing DHA/EPA omega-3, especially those with a low intake of oily fish.