SkinCeuticals Phloretin CF Serum

Product Information

A mineral tinted fluid, this daily sunscreen is suitable for all skin types and instantly helps improve the appearance of uneven skin tone while protecting the skin from further discoloration and damage. Featuring micro-fine zinc oxide (Z-Cote®) and titanium dioxide to provide broad spectrum protection against UVA/UVB rays, this ultra-sheer, non-irritating formula is infused with artemia salina to enhance the skin’s natural defenses against UV- and heat-induced stress, plus translucent color spheres that help even out skin tone and boost skin’s radiance upon application. With a paraben- and fragrance-free, non-comedogenic formula that’s ideal for all skin types (including sensitive), this lightweight, water-resistant fluid provides a touch of coverage and leaves skin with a soft, radiant finish as well as no white cast. For evening use: Retinol 0.3, 0.5 or 1.0 The most common skin concern during pregnancy is hyperpigmenation. According to the British Association of Dermatologists, it can affect up to 50% of women during their pregnancy, because hormones are slightly out of kilter and your body starts to produce more oestrogen. Combined with an increase in photosensitivity, this presents itself as large patches of discolouration on the face. The increase in oestrogen is also why your areola (the round area around your nipples) darkens.

In other words, for me, Skinceuticals CE Ferulic wins hands down in every respect. But hey, if you’re curious to try Phloretin, you’ll still get a few antioxidant benefits. How Does Skinceuticals Phloretin CF Compare To The Other Skinceuticals Vitamin C Serums? Another way that ascorbic acid helps to reduce signs of aging is through collagen synthesis. Specifically, ascorbic acid serves as a cofactor for prolysyl and lysyl hydroxylase, the enzymes that are responsible for stabilizing and cross-linking the collagen molecules. Thus, SkinCeuticals Phloretin CF may be able to help reduce the appearance of fine lines and wrinkles while promoting firmer, more youthful skin. The nonalcoholic fatty liver disease (NAFLD) experimental model is routinely used for the evaluation of therapeutic agents targeting the various components of metabolic dysfunction associated with lipids. By using Huh7 cells exposed to high doses of free fatty acids, Chhimwal et al. [ 68] have shown that phloretin encouraged autophagy-mediated hepatic lipid clearance and restored mitochondrial membrane potential and redox homeostasis. In the in vivo model of NAFLD using mice subjected to a western diet, a reduction in hepatic histological injury, hepatic lipogenesis, and enhanced fatty acid oxidation were observed in phloretin (50, 100, and 200 mg/kg, p.o.)-treated animals. While improving body weight, oral glucose tolerance, and antioxidant status in the liver (increased levels of SOD, CAT, and decreased lipid peroxidation products, malondialdehyde (MDA) status, a reduction in inflammation was evident as demonstrated by diminished levels of TNF-α and IL-6 in the liver. Beyond the anti-inflammatory effect, phloretin restored the AMPK activity (induction of phosphorylation of AMPK) in the liver of NAFLD and fatty acids-loaded hepatocyte cell lines. The activity of PPARα and its target genes carnitine palmitoyltransferase 1 (CPT1) and CPT2, as well as fatty acids metabolism in the liver, was also augmented by phloretin supplementation in the diet. Pure vitamin C (l-ascorbic acid): lauded for its superior antioxidant benefits, this highly potent form of pure vitamin C neutralizes damaging free radicals and protects against oxidative stress while providing visible anti-aging benefits.The serum has an unusual consistency. It’s watery, yet it has a slight oil feel to it. It sinks into the skin immediately. I personally don’t mind it, but if you have very oily skin, it’s something to consider. Fragrance Supporting the role of mitogen-activated protein kinases (MAPK) pathway in the anti-inflammatory effect of phloretin, inhibition of the LPS-stimulated phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and JNK was reported in the RAW 264.7 cells [ 36]. These three main kinases (ERK, p38, and JNK) are activated by various inflammatory stimuli and convert the extracellular response to signalling pathways often through crosstalk with the NF-κB-mediated gene activation. The inhibitory effect of polyphenols such as gallic acid and proanthocyanidins against proinflammatory cytokines release and NF-κB activation in the LPS-stimulated RAW 264.7 macrophages has been shown to be mediated through inhibition of the ERK, p38, and JNK [ 52, 53]. When mouse dendritic cells were stimulated by LPS, the TLR4-mediated ROS, MAPKs (ERK, JNK, and p38 MAPK), and NF-κB as well as the production of proinflammatory cytokines and chemokines were shown to be suppressed by phloretin [ 54]. As shown further in the later sections, phloretin appears to modulate its anti-inflammatory effect partly through altering the proinflammatory mediators-induced upstream cell signalling cascades involving the MAPKs. Experienced retinol users generally tolerate a higher concentration. Once your skin is comfortable with Retinol 0.3, you may step up to Retinol 0.5. This concentration can also be used by first-timers with resistant skin that rarely experiences irritation. aqua / water / eau, dipropylene glycol, alcohol denat., ascorbic acid, butylene glycol, triethyl citrate, phloretin, ferulic acid About Gio Groundbreaking for its day, it has now become the gold standard for Vitamin C serums and inspired a long string of dupes (and lawsuits). Now they’re bringing another innovation, 15% L-Ascorbic Acid (Vitamin C) + Ferulic Acid + Phloretin. Will it be as successful as its predecessor? Only time will tell. Key Ingredients In Skinceuticals Phloretin CF: What Makes It Work?

SkinCeuticals Phloretin CF Antioxidant Vitamin C Discoloration Serumis a patented triple antioxidant formulation that visibly improves the appearance of discoloration, fine lines and uneven skin tone. This potent vitamin C serum features a synergistic combination of 2% phloretin, 10% pure vitamin C (l-ascorbic acid), and 0.5% ferulic acid. These antioxidants provide powerful antioxidant protection against atmospheric skin aging – environmental damage and premature signs of aging caused by free radicals from UVA/UVB, infrared radiation (IRA), and ozone pollution (O3). Text, Behind the formula. Phloretin CF. A bottle of SkinCeuticals Phloretin CF appears as a model turns to us. Icons representing free radicals appear. Text, Pollution, Blue Light, Chemicals, U V.

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In a diabetic neuropathy study induced by STZ, phloretin (50 or 25 mg/kg, i.p.) or in combination with duloxetine (15 mg/kg duloxetine and 25 mg/kg phloretin, i.p.) was shown to ameliorate the thermally induced hyperalgesia, sciatic nerve oxidative stress markers (tissue MDA, NO, SOD activity and GSH levels); and sciatic nerve TNF-α and IL-6 levels [ 107]. This, together with the normalization of histopathological and structural changes, suggests the potential of phloretin as a neuroprotective agent. In HFD- and STZ-induced diabetes models in mice, phlorizin (10–20 mg/kg, p.o.) was shown to alleviate depression symptoms, reversed the decline in GSH, BDNF, and its receptor (TrkB), cyclic AMP-responsive element-binding protein (CREB) and ERK level [ 108]. Inflammatory markers were not, however, assessed in this study. Alcohol Denat is one of the most misunderstood ingredients in skincare. Word on the street is that it’s terribly drying and irritating.