Anatomic Line Cryogel Muscle & Joint Pain Relief Gel for Back, Neck & Shoulders Ache 100ml

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Zhang, X.; Hang, Y.; Ding, Z.; Xiao, L.; Cheng, W.; Lu, Q. Macroporous Silk Nanofiber Cryogels with Tunable Properties. Biomacromolecules 2022, 23, 2160–2169. [ Google Scholar] [ CrossRef] Memic, A.; Colombani, T.; Eggermont, L.J.; Rezaeeyazdi, M.; Steingold, J.; Rogers, Z.J.; Navare, K.J.; Mohammed, H.S.; Bencherif, S.A. Latest Advances in Cryogel Technology for Biomedical Applications. Adv. Ther. 2019, 2, 1800114. [ Google Scholar] [ CrossRef][ Green Version] M. V. Khedkar, S. B. Somvanshi, A. V. Humbe and K. Jadhav, Surface modified sodium silicate based superhydrophobic silica aerogels prepared via ambient pressure drying process, J. Non-Cryst. Solids, 2019, 511, 140–146 CrossRef CAS. Eggermont,L.J.; Rogers,Z.J.; Colombani,T.; Memic,A.; Bencherif,S.A. TrendsBiotechnol. 2020, 38, 418–431. doi:10.1016/j.tibtech.2019.09.008

Baptista, M.; Joukhdar, H.; Alcala-Orozco, C.R.; Lau, K.; Jiang, S.; Cui, X.; He, S.; Tang, F.; Heu, C.; Woodfield, T.B. Silk fibroin photo-lyogels containing microchannels as a biomaterial platform for in situ tissue engineering. Biomater. Sci. 2020, 8, 7093–7105. [ Google Scholar] [ CrossRef] Cryogels comprising the natural biopolymers silk fibroin and chitosan, with tannic acid and ferric ions (Fe 3+) incorporated have been reported as multifunctional devices for wound healing providing hemostasis, exudate absorbance, antibacterial effects, and promotion of cell proliferation [117]. The tannic acid and ferric ions provide photothermal properties whereby under near infrared (NIR) radiation the temperature increased to enhance the antimicrobial properties, while also showing good hemostasis properties such as blood absorption and clotting, and cell proliferation. Chitosan has also been used by Meena et al. for producing cryogels for haemostatic applications, with locust bean gum (LBG) incorporated to enhance mechanical properties and water absorption [32]. This chitosan/LBG semi-interpenetrating network cryogel was investigated for its swelling, degradation, and protein adsorption properties, demonstrating potential as a haemostatic dressing.Kadakia, P.; Jain, E.; Hixon, K.; Eberlin, C.; Sell, S. Sonication induced silk fibroin cryogels for tissue engineering applications. Mater. Res. Express 2016, 3, 055401. [ Google Scholar] [ CrossRef]

While cryogels have been investigated by researchers for decades, they are now finding applications in a broad range of biomedical settings due to their interconnected porosity and advantageous properties. A major advantage of cryogels is their low-cost manufacturing due to the medium of porogens commonly used being water, and relatively low amounts of reagent required. However, there are issues when considering scaling up cryogel syntheses. Yetiskin, B.; Akinci, C.; Okay, O. Cryogelation within cryogels: Silk fibroin scaffolds with single-, double- and triple-network structures. Polymer 2017, 128, 47–56. [ Google Scholar] [ CrossRef] Commonwealth Scientific and Industrial Research Organisation (CSIRO), Materials Science and Engineering, Clayton, VIC 3168, Australia Bölgen,N.; Plieva,F.; Galaev,I.Y.; Mattiasson,B.; Pişkin,E. J.Biomater.Sci.,Polym.Ed. 2007, 18, 1165–1179. doi:10.1163/156856207781554064 C. Garnier, T. Muneer and L. McCauley, Super insulated aerogel windows: Impact on daylighting and thermal performance, Building and Environment, 2015, 94, 231–238 CrossRef.

P. C. Thapliyal and K. Singh, Aerogels as promising thermal insulating materials: An overview, J. Mater, 2014, 2014(1), 1–10 Search PubMed. Cryogels offer solutions to obstacles in current medicinal and therapeutic practices. In particular, specific isolation and characterisation of stem cells in cell-based therapies, detection of low levels of biomarkers in the blood (i.e., tumour cells, pathogenic microorganisms, etc.) for disease diagnosis, and general isolation of biological substances for clinical and environmental microbiology hold opportunities for cryogels [13,42,61]. They also allow for the processing of cell and virus suspensions and support microbiological research in studying interactions between different biological substances (i.e., cell–virus interactions) [38].

Stimuli-responsive properties are often desirable for biomaterials used in drug-delivery applications. Here, we focus on temperature and solution pH response of cryogels as detailed below. 3.1. Temperature-responsive cryogels Mallepally, R.R.; Marin, M.A.; Surampudi, V.; Subia, B.; Rao, R.R.; Kundu, S.C.; McHugh, M.A. Silk fibroin aerogels: Potential scaffolds for tissue engineering applications. Biomed. Mater. 2015, 10, 035002. [ Google Scholar] [ CrossRef] Villard, P.; Rezaeeyazdi, M.; Colombani, T.; Joshi-Navare, K.; Rana, D.; Memic, A.; Bencherif, S.A. Autoclavable and Injectable Cryogels for Biomedical Applications. Adv. Healthc. Mater. 2019, 8, 1900679. [ Google Scholar] [ CrossRef] Gholipourmalekabadi, M.; Sapru, S.; Samadikuchaksaraei, A.; Reis, R.L.; Kaplan, D.L.; Kundu, S.C. Silk fibroin for skin injury repair: Where do things stand? Adv. Drug Del. Rev. 2020, 153, 28–53. [ Google Scholar] [ CrossRef] Li, G.; Sun, S. Silk fibroin-based biomaterials for tissue engineering applications. Molecules 2022, 27, 2757. [ Google Scholar] [ CrossRef]S. He, D. Huang, H. Bi, Z. Li, H. Yang and X. Cheng, Synthesis and characterization of silica aerogels dried under ambient pressure bed on water glass, J. Non-Cryst. Solids, 2015, 410, 58–64 CrossRef CAS.